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There is little diffusion into the CSF when the meninges are not inflamed. Data from animal studies indicate that azithromycin crosses the placenta. Small amounts of azithromycin are demethylated in the liver, and it is excreted in bile mainly as unchanged drug and a number of inactive metabolites have also been detected. The terminal elimination half-life is about 68 hours. Uses and Administration Azithromycin is a nitrogen-containing macrolide azalide with actions and uses similar to those of erythromycin. It is given in the treatment of respiratory-tract infections including otitis media , in skin and soft-tissue infections, and in uncomplicated genital infections. Azithromycin may also be used for the prophylaxis, and as a component of regimens in the treatment, of Mycobacterium avium complex MAC infections. It is used in some countries for the prophylaxis of endocarditis in atrisk patients unable to take penicillin.

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